The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness - The amsterdam growth and health longitudinal study

被引:155
作者
Ferreira, I
Henry, RMA
Twisk, JWR
van Mechelen, W
Kemper, HCG
Stehouwer, CDA
机构
[1] Erasmus Univ, Ctr Med, Dept Publ Hlth, NL-3000 DR Rotterdam, Netherlands
[2] Vrije Univ Amsterdam, Inst Res Extramural Med, NL-1081 HV Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Dept Clin Epidemiol & Biostat, NL-1081 HV Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Res Ctr Phys Activ Work & Hlth, TNOVU,Dept Social Med & Body Work, NL-1081 HV Amsterdam, Netherlands
[5] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, NL-1081 HV Amsterdam, Netherlands
[6] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, NL-1081 HV Amsterdam, Netherlands
[7] Univ Hosp Maastricht, Dept Internal Med, Maastricht, Netherlands
[8] Univ Hosp Maastricht, Inst Cardiovasc Res, Maastricht, Netherlands
关键词
D O I
10.1001/archinte.165.8.875
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The mechanisms that link the metabolic syndrome to increased cardiovascular risk are incompletely understood, especially in young people. We therefore examined whether the metabolic syndrome was associated with arterial stiffness and whether any such associations were independent of cardiopulmonary fitness and subcutaneous trunk fat. Methods: Cross-sectional analyses of data on 364 men and women aged 36 years from the Amsterdam Growth and Health Longitudinal Study (ninth follow-up measurement, year 2000). The prevalence of the metabolic syndrome was defined by a slightly modified National Cholesterol Education Program (NCEP) definition. Arterial stiffness was ultrasonically estimated by distensibility and compliance of the carotid, femoral, and brachial arteries and by the carotid elastic modulus. Results: The prevalence of the metabolic syndrome in this young adult population was 18.3% in men and 3.2% in women. individuals with the syndrome compared with individuals without risk factors had 11.2% and 17.0% less distensibility and 9.0% and 18.2% less compliance of the carotid and femoral arteries, respectively, and 15.9% higher carotid elastic modulus. After adjustment for cardiopulmonary fitness and subcutaneous trunk fat, the metabolic syndrome remained significantly associated with stiffness of the carotid but not the femoral artery. in addition, poor cardiopulmonary fitness and high subcutaneous trunk fat were associated with arterial stiffness, and this was independent of the metabolic syndrome. Conclusions: A modified NCEP definition of the metabolic syndrome identified young individuals with increased arterial stiffness. The mechanisms that link the metabolic syndrome, poor cardiopulmonary fitness, and high subcutaneous trunk fat to greater arterial stiffness overlap but are partly independent of each other.
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收藏
页码:875 / 882
页数:8
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