Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis

被引：34

作者：

Bartosik-Psujek, Halina ^{[1
,2
]}

Tabarkiewicz, Jacek ^{[3
,4
]}

Pocinska, Krystyna ^{[1
,2
]}

Stelmasiak, Zbigniew ^{[1
,2
]}

Rolinski, Jacek ^{[3
,4
]}

机构：

[1] Med Univ Lublin, Dept Neurol, PL-20090 Lublin, Poland

[2] Med Univ Lublin, Chair Neurol, PL-20090 Lublin, Poland

[3] Med Univ Lublin, Chair Clin Immunol, PL-20090 Lublin, Poland

[4] Med Univ Lublin, Dept Clin Immunol, PL-20090 Lublin, Poland

来源：

MULTIPLE SCLEROSIS | 2010年 / 16卷 / 12期

关键词：

dendritic cells; multiple sclerosis; vitamin D; RECEPTOR;

D O I：

10.1177/1352458510379611

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In order to evaluate the effects of vitamin D3 on monocyte-derived dendritic cells (DCs) of relapsing-remitting multiple sclerosis patients, DCs differentiation and maturation were evaluated in vitro based on surface phenotypic changes. The expression of CD14, CD83, CD1a, CD80, CD86, CD206 and C209 was analysed by fluorescence-activated cell sorting. The results reveal that vitamin D3 inhibits both the differentiation and maturation of DCs. Moreover, inhibits the secretion of IL 23/12p40 and increases the secretion of CCL2. The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.

引用

页码：1513 / 1516

页数：4

共 11 条

[1] Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists [J].

Adorini, Luciano ;

Penna, Giuseppe .

HUMAN IMMUNOLOGY, 2009, 70 (05) :345-352

[2] Mechanisms of disease - The many roles of chemokines and chemokine receptors in inflammation [J].

Charo, IF ;

Ransohoff, RM .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :610-621

[3]

Embry AF, 2000, ANN NEUROL, V48, P271, DOI 10.1002/1531-8249(200008)48:2<271::AID-ANA28>3.0.CO

[4]

2-O

[5] Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses [J].

Geijtenbeek, TBH ;

Torensma, R ;

van Vliet, SJ ;

van Duijnhoven, GCF ;

Adema, GJ ;

van Kooyk, Y ;

Figdor, CG .

CELL, 2000, 100 (05) :575-585

[6] Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs:: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo [J].

Griffin, MD ;

Lutz, W ;

Phan, VA ;

Bachman, LA ;

McKean, DJ ;

Kumar, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6800-6805

[7] Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis [J].

Hiremath, G. S. ;

Cettomai, D. ;

Baynes, M. ;

Ratchford, J. N. ;

Newsome, S. ;

Harrison, D. ;

Kerr, D. ;

Greenberg, B. M. ;

Calabresi, P. A. .

MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (06) :735-740

[8] Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis [J].

Munger, Kassandra L. ;

Levin, Lynn I. ;

Hollis, Bruce W. ;

Howard, Noel S. ;

Ascherio, Alberto .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (23) :2832-2838

[9] Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells [J].

Piemonti, L ;

Monti, P ;

Sironi, M ;

Fraticelli, P ;

Leone, BE ;

Dal Cin, E ;

Allavena, P ;

Di Carlo, V .

JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4443-4451

[10] The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids [J].

Porcelli, SA ;

Modlin, RL .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :297-329

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