Local administration of serotonin agonists blocks light-induced phase advances of the circadian activity rhythm in the hamster

被引:84
作者
Weber, ET [1 ]
Gannon, RL [1 ]
Rea, MA [1 ]
机构
[1] USAF, Res Lab, HEPM, Biol Rhythms & Integrat Neurosci Res Inst, Brooks AFB, TX 78235 USA
关键词
serotonin; circadian; suprachiasmatic; photic entrainment; biological rhythm;
D O I
10.1177/074873098129000057
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Circadian rhythms in mammals are synchronized to environmental light-dark cycles through a direct retinal projection to the suprachiasmatic nucleus (SCN), a circadian clock. This process is thought to be modulated by other afferents to the SCN, including a dense serotonergic projection from the midbrain raphe. Previous work from this laboratory demonstrated that a systemically administered 5-hydroxyhyptamine(1A/7) (5-HT1A/7) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) dose dependently attenuates Light-induced phase shifts of the circadian activity rhythm of the Syrian hamster. In this study, we demonstrate that local injections (1-100 mu M) of the 5-HT1A/7 agonists 8-OH-DPAT or 5-carboxamidotryptamine into the region of the SCN inhibit light-induced phase advances of the circadian wheel-running rhythm. In addition, the inhibitory effects of systemically administered 8-OH-DPAT were unaffected by either radiofrequency-induced lesions of the intergeniculate leaflet or 5,7-dihydroxytryptamine-induced lesions of serotonergic projections to the SCN. These findings support a modulatory role of serotonin in photic regulation of circadian phase through an action at the level of the SCN.
引用
收藏
页码:209 / 218
页数:10
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