Monoclonal antibodies against Epstein-Barr virus cross-react with α-synuclein in human brain

被引：32

作者：

Woulfe, J

Hoogendoorn, H

Tarnopolsky, M

Muñoz, DG

机构：

[1] McMaster Univ, Dept Pathol & Mol Med, Hamilton, New Zealand

[2] Hamilton Hlth Sci Corp, Hamilton Reg Lab Med Program, Hamilton, New Zealand

[3] HCH Res Ctr, Hamilton, New Zealand

[4] McMaster Univ, Med Ctr, Dept Med, Div Neurol, Hamilton, New Zealand

[5] Univ Western Ontario, Dept Pathol, London, ON, Canada

[6] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada

[7] Doce Octubre Hosp, Neurol Serv, Madrid, Spain

来源：

NEUROLOGY | 2000年 / 55卷 / 09期

关键词：

D O I：

10.1212/WNL.55.9.1398

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using antibodies generated against the latent membrane protein 1 of Epstein-Barr virus, intense immunoreactivity of Lewy bodies (in PD and dementia with Lewy bodies) and glial cytoplasmic inclusions (in multiple system atrophy) was demonstrated. ELISA and Western blotting techniques confirmed that this immunolabeling was due to cross-reactivity of the antiviral antibody with alpha -synuclein, a neuronal protein implicated in the pathogenesis of PD. This example of cross-reactivity between Epstein-Barr virus and alpha -synuclein may bear implications for further elucidating infectious or autoimmune mechanisms in PD.

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页码：1398 / 1401

页数：4

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