CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination

被引：24

作者：

Busshoff, U

Hein, A

Iglesias, A

Dörries, R

Régnier-Vigouroux, A

机构：

[1] Heidelberg Univ, Interdisziplinares Zentrum Neurowissensch, Dept Neurobiol, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Klinikum Mannheim, Inst Med Mikrobiol & Hyg, D-68167 Mannheim, Germany

[3] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 113卷 / 02期

关键词：

CD1; central nervous system; microglia; leukocytes; experimental autoimmune encephalomyelitis;

D O I：

10.1016/S0165-5728(00)00450-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Expression of CD1 by microglia, macrophages and T cells was investigated ex vivo. In the healthy central nervous system (CNS), resident microglia, macrophages and T cells express levels of CD1 significantly lower than that expressed by splenic macrophages and T cells. During experimental autoimmune encephalomyelitis (EAE), CD1 expression by microglia and the number of CD1(+) microglia increase. Macrophages and T cells strongly upregulate CD1 expression in the CNS, but not in the spleen. Whereas the function of CD1 expressed by T cells remains unclear, the expression by microglia and macrophages provides the CNS with a (glyco)lipidic-presenting molecule in an inflammatory and demyelinating environment. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：220 / 230

页数：11

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