Mild ovarian stimulation for IVF: 10 years later

被引：89

作者：

Fauser, Bart C. J. M. ^{[1
]}

Nargund, Geeta ^{[2
]}

Andersen, Anders Nyboe ^{[3
]}

Norman, Robert ^{[4
]}

Tarlatzis, Basil ^{[5
]}

Boivin, Jacky ^{[6
]}

Ledger, William ^{[7
]}

机构：

[1] Univ Med Ctr, Dept Reprod Med & Gynaecol, Utrecht, Netherlands

[2] St Georges Hosp & Med Sch, Dept Reprod Med, London, England

[3] Copenhagen Univ Hosp, Rigshosp, Fertil Clin, Copenhagen, Denmark

[4] Univ Adelaide, Sch Pediat & Reprod Hlth, Discipline Obstet & Gynaecol, Robinson Inst, Adelaide, SA, Australia

[5] Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, GR-54006 Thessaloniki, Greece

[6] Cardiff Univ, Sch Psychol, Cardiff, S Glam, Wales

[7] Univ Sheffield, Acad Unit Reprod & Dev Med, Sheffield, S Yorkshire, England

来源：

HUMAN REPRODUCTION | 2010年 / 25卷 / 11期

关键词：

mild ovarian stimulation; IVF; GnRH antagonist; infertility; FSH; IN-VITRO FERTILIZATION; NATURAL CYCLE IVF; CLOMIPHENE CITRATE; COST-EFFECTIVENESS; LIVE BIRTH; CLINICAL CONSEQUENCES; TREATMENT STRATEGY; FOLLICULAR PHASE; GNRH ANTAGONISTS; RECOMBINANT FSH;

D O I：

10.1093/humrep/deq247

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Ovarian stimulation to achieve multiple follicle development has been an integral part of IVF treatment. In the context of improved laboratory performance, the need for a large number of oocytes as an integral part of a successful IVF programme may be questioned. The aim of the current debate is to summarize the studies performed during the last decade to develop the concept of mild stimulation aiming to obtain fewer than eight oocytes. Here we examine the balance between IVF success and patient discomfort, and complications and cost, and how these might improve by simpler ovarian stimulation protocols aimed at retrieving fewer oocytes. We intend to analyse why progress has been rather slow and why there is much resistance to mild stimulation. Finally, presumed useful directions for future research will be discussed.

引用

页码：2678 / 2684

页数：7

共 50 条

[1]

Modified natural cycle IVF and mild IVF: a 10 year Swedish experience [J].

Aanesen, Arthur ;

Nygren, Karl-Gosta ;

Nylund, Lars .

REPRODUCTIVE BIOMEDICINE ONLINE, 2010, 20 (01) :156-162

[2]

Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo:: a randomized controlled trial [J].

Baart, Esther B. ;

Martini, Elena ;

Eijkemans, Marinus J. ;

Van Opstal, Diane ;

Beckers, Nicole G. M. ;

Verhoeff, Arie ;

Macklon, Nicolas S. ;

Fauser, Bart C. J. M. .

HUMAN REPRODUCTION, 2007, 22 (04) :980-988

[3]

Can 200 IU of hCG replace recombinant FSH in the late follicular phase in a GnRH-antagonist cycle? A pilot study [J].

Blockeel, C. ;

De Vos, M. ;

Verpoest, W. ;

Stoop, D. ;

Haentjens, P. ;

Devroey, P. .

HUMAN REPRODUCTION, 2009, 24 (11) :2910-2916

[4]

Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression [J].

Branigan, EF ;

Estes, MA .

FERTILITY AND STERILITY, 2000, 73 (03) :587-590

[5]

Ovarian Aging: Mechanisms and Clinical Consequences [J].

Broekmans, F. J. ;

Soules, M. R. ;

Fauser, B. C. .

ENDOCRINE REVIEWS, 2009, 30 (05) :465-493

[6]

The psychological impact more cycles of IVF with a treatment strategy of IVF failure after two or mild versus standard [J].

de Klerk, C. ;

Macklon, N. S. ;

Heijnen, E. M. E. W. ;

Eijkemans, M. J. C. ;

Fauser, B. C. J. M. ;

Passchier, J. ;

Hunfeld, J. A. M. .

HUMAN REPRODUCTION, 2007, 22 (09) :2554-2558

[7]

World Collaborative Report on Assisted Reproductive Technology, 2002 [J].

de Mouzon, Jacques ;

Lancaster, Paul ;

Nygren, Karl Gosta ;

Sullivan, Elisabeth ;

Zegers-Hochschild, Fernando ;

Mansour, Ragaa ;

Ishihara, Osamu ;

Adamson, David .

HUMAN REPRODUCTION, 2009, 24 (09) :2310-2320

[8]

Reproductive biology and IVF: ovarian stimulation and endometrial receptivity [J].

Devroey, P ;

Bourgain, C ;

Macklon, NS ;

Fauser, BCJM .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (02) :84-90

[9]

Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment [J].

Devroey, Paul ;

Aboulghar, Mohamed ;

Garcia-Velasco, Juan ;

Griesinger, Georg ;

Humaidan, Peter ;

Kolibianakis, Efstratios ;

Ledger, William ;

Tomas, Candido ;

Fauser, Bart C. J. M. .

HUMAN REPRODUCTION, 2009, 24 (04) :764-774

[10]

Cost-effectiveness analysis of different embryo transfer strategies in England [J].

Dixon, S. ;

Nasiri, F. Faghih ;

Ledger, W. L. ;

Lenton, E. A. ;

Duenas, A. ;

Sutcliffe, P. ;

Chilcott, J. B. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2008, 115 (06) :758-766

← 1 2 3 4 5 →