Cerebral β-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage

被引：30

作者：

Ly, John V. ^{[2
]}

Rowe, Christopher C. ^{[3
]}

Villemagne, Victor L. ^{[3
]}

Zavala, Jorge A. ^{[2
]}

Ma, Henry ^{[2
]}

O'Keefe, Graeme ^{[3
]}

Gong, Sylvia J. ^{[3
]}

Gunawan, Rico ^{[2
]}

Churilov, Leonid ^{[2
]}

Saunder, Tim ^{[3
]}

Ackerman, Uwe ^{[3
]}

Tochon-Danguy, Henri ^{[3
]}

Donnan, Geoffrey A. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Florey Neurosci Inst, Carlton, Vic 3053, Australia

[2] Univ Melbourne, Natl Stroke Res Inst, Heidelberg Hts, Australia

[3] Ctr PET, Dept Nucl Med, Heidelberg, Vic, Australia

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 06期

关键词：

ACUTE ISCHEMIC-STROKE; INTRACEREBRAL HEMORRHAGE; THROMBOLYTIC THERAPY; INTRACRANIAL HEMORRHAGE; TRANSFORMATION; PREDICTORS; ANGIOPATHY; ALTEPLASE; BINDING; BURDEN;

D O I：

10.1002/ana.22072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound 3 (PiB) (a cerebral beta-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, suggesting underlying CAA as a predisposing factor for rt-PA related hemorrhage. This finding may provide an impetus for the development of a more practical rapid pretreatment screening technique. ANN NEUROL 2010;68:959-962

引用

页码：959 / 962

页数：4

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