Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

被引：268

作者：

Patel, NV

Gordon, MN

Connor, KE

Good, RA

Engelman, RW

Mason, J

Morgan, DG

Morgan, TE ^{[1
]}

Finch, CE

机构：

[1] Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA

[3] Univ S Florida, Dept Pharmacol, Alzheimers Res Lab, Tampa, FL 33162 USA

[4] Univ S Florida, Dept Pediat, Alzheimers Res Lab, Tampa, FL 33162 USA

来源：

NEUROBIOLOGY OF AGING | 2005年 / 26卷 / 07期

关键词：

caloric restriction; AD transgenics; amyloid deposition; astrocyte activation;

D O I：

10.1016/j.neurobiolaging.2004.09.014

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging processes are attenuated in laboratory mammals by caloric restriction (CR), we examined the effects of short-term CR in two AD-transgenic mice, APP(swe/ind) (J20) and APP(swe) + PS1(M146L) (APP+PS1), CR substantially decreased the accumulation of A beta-plaques in both lines: by 40% in APP(swe/ind) (CR, 6 weeks), and by 55% in APP + PS1 (CR, 14 weeks). CR also decreased astrocytic activation (GFAP immunoreactivity). These influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：995 / 1000

页数：6

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