The synthesis of amino-acid functionalized β-carbolines as topoisomerase II inhibitors

被引：98

作者：

Deveau, AM ^{[1
]}

Labroli, MA ^{[1
]}

Dieckhaus, CM ^{[1
]}

Barthen, MT ^{[1
]}

Smith, KS ^{[1
]}

Macdonald, TL ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)00136-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of amino acid functionalized beta -carboline derivatives, which are structurally related to azatoxin and the tryprostatins, are reported. These compounds were assayed for their growth inhibition properties in H520 and PC3 cell lines and were examined for their abilities to inhibit topoisomerase II-mediated DNA relaxation. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1251 / 1255

页数：5

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