15-year incidence of diabetic ketoacidosis at onset of type 1 diabetes in children from a regional setting (Auckland, New Zealand)

被引：55

作者：

Jefferies, Craig ^{[1
]}

Cutfield, Samuel W. ^{[2
]}

Derraik, Jose G. B. ^{[2
]}

Bhagvandas, Jignal ^{[1
]}

Albert, Benjamin B. ^{[2
]}

Hofman, Paul L. ^{[2
,4
]}

Gunn, Alistair J. ^{[3
]}

Cutfield, Wayne S. ^{[2
,4
]}

机构：

[1] Starship Childrens Hosp, Auckland Dist Hlth Board, Auckland, New Zealand

[2] Univ Auckland, Liggins Inst, Auckland 1, New Zealand

[3] Univ Auckland, Dept Physiol, Auckland, New Zealand

[4] Gravida Natl Ctr Growth & Dev, Auckland, New Zealand

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

INITIAL PRESENTATION; AUSTRIAN CHILDREN; DIAGNOSIS; FREQUENCY;

D O I：

10.1038/srep10358

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

We assessed the incidence of diabetic ketoacidosis (DKA) in children aged <15 years with newly diagnosed type 1 diabetes mellitus (T1DM) in the Auckland Region (New Zealand) in 1999-2013, in a retrospective review of a complete regional cohort. DKA and its severity were classified according to ISPAD 2014 guidelines. Of 730 children presenting with new-onset T1DM over the 15-year time period, 195 cases had DKA of any severity (27%). There was no change in the incidence of DKA or the proportion of children with severe DKA at presentation. The incidence of DKA among children aged <2.0 years (n = 40) was 53% compared to 25% for those aged 2-14 years (n = 690; p = 0.005). In children aged 2-14 years, increasing age at diagnosis was associated with greater likelihood of DKA at presentation (p = 0.025), with the odds of DKA increasing 1.06 times with each year increase in age. Non-Europeans were more likely to present in DKA than New Zealand Europeans (OR 1.52; p = 0.048). Despite a consistent secular trend of increasing incidence of T1DM, there was no reduction in the incidence of DKA in new-onset T1DM in the Auckland Region over time. Thus, it is important to explore ways to reduce DKA risk.

引用

页数：7

共 34 条

[1]

Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999 [J].

Bessaoud, K. ;

Boudraa, G. ;

Molinero de Ropolo, M. ;

de Sereday, M. ;

Marti, M. L. ;

Moser, M. ;

Lapertosa, S. ;

Damiano, M. ;

Verge, C. ;

Howard, N. ;

Schober, E. ;

Jordan, O. ;

Weets, I. ;

Gorus, F. ;

Coeckelberghs, M. ;

Rooman, R. ;

Van Gaal, L. ;

Franco, L. J. ;

Ferreira, S. R. G. ;

Lisboa, H. P. K. ;

Kurtz, L. A. ;

Graebin, R. ;

Kutzke, L. ;

Rodriges, C. ;

Savova, R. ;

Christov, V. ;

Iotova, V. ;

Tzaneva, V. ;

Pacaud, D. ;

Toth, E. ;

Tan, M. H. ;

Carrasco, E. ;

Perez, F. ;

Ze, Y. ;

Bo, Y. ;

Chen, S. ;

Fu, L. ;

Deng, L. ;

Shen, S. ;

Teng, K. ;

Wang, C. ;

Jian, H. ;

Ju, J. ;

Yan, C. ;

Ze, Y. ;

Deng, Y. ;

Li, C. ;

Zhang, Y. ;

Liu, Y. ;

Long, X. .

DIABETIC MEDICINE, 2006, 23 (08) :857-866

[2]

Neurological Consequences of Diabetic Ketoacidosis at Initial Presentation of Type 1 Diabetes in a Prospective Cohort Study of Children [J].

Cameron, Fergus J. ;

Scratch, Shannon E. ;

Nadebaum, Caroline ;

Northam, Elisabeth A. ;

Koves, Ildiko ;

Jennings, Juliet ;

Finney, Kristina ;

Neil, Jeffrey J. ;

Wellard, R. Mark ;

Mackay, Mark ;

Inder, Terrie E. .

DIABETES CARE, 2014, 37 (06) :1554-1562

[3]

Prospective incidence study of diabetes mellitus in New Zealand children aged 0 to 14 years [J].

Campbell-Stokes, PL ;

Taylor, BJ .

DIABETOLOGIA, 2005, 48 (04) :643-648

[4]

Ethnicity and social deprivation independently influence metabolic control in children with type 1 diabetes [J].

Carter, P. J. ;

Cutfield, W. S. ;

Hofman, P. L. ;

Gunn, A. J. ;

Wilson, D. A. ;

Reed, P. W. ;

Jefferies, C. .

DIABETOLOGIA, 2008, 51 (10) :1835-1842

[5]

Ketoacidosis at diagnosis of type 1 diabetes in French children and adolescents [J].

Choleau, C. ;

Maitre, J. ;

Pierucci, A. Filipovic ;

Elie, C. ;

Barat, P. ;

Bertrand, A. -M. ;

de Kerdanet, M. ;

Letallec, C. ;

Levy-Marchal, C. ;

Nicolino, M. ;

Tubiana-Rufi, N. ;

Cahane, M. ;

Robert, J. J. .

DIABETES & METABOLISM, 2014, 40 (02) :137-142

[6]

Consistently high incidence of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes [J].

Claessen, Femke M. A. P. ;

Donaghue, Kim ;

Craig, Maria .

MEDICAL JOURNAL OF AUSTRALIA, 2012, 197 (04) :216-216

[7]

Trends in the Prevalence of Ketoacidosis at Diabetes Diagnosis: The SEARCH for Diabetes in Youth Study [J].

Dabelea, Dana ;

Rewers, Arleta ;

Stafford, Jeanette M. ;

Standiford, Debra A. ;

Lawrence, Jean M. ;

Saydah, Sharon ;

Imperatore, Giuseppina ;

D'Agostino, Ralph B., Jr. ;

Mayer-Davis, Elizabeth J. ;

Pihoker, Catherine .

PEDIATRICS, 2014, 133 (04) :E938-E945

[8]

Factors associated with diabetic ketoacidosis at onset of Type 1 diabetes in children and adolescents [J].

de Vries, L. ;

Oren, L. ;

Lazar, L. ;

Lebenthal, Y. ;

Shalitin, S. ;

Phillip, M. .

DIABETIC MEDICINE, 2013, 30 (11) :1360-1366

[9]

Decrease in frequency of ketoacidosis at diabetes onset over the past two decades - perspectives of a paediatric tertiary care centre [J].

de Vries, L. ;

Oren, L. ;

Lebenthal, Y. ;

Shalitin, S. ;

Lazar, L. ;

Phillip, M. .

DIABETIC MEDICINE, 2012, 29 (08) :E170-E175

[10]

Delderfield M., 2005, SDS INDIVIDUAL CALCU

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