Sequence-dependent fluorescence of DNA-hosted silver nanoclusters

被引:400
作者
Gwinn, Elisabeth G. [1 ,2 ]
O'Neill, Patrick [1 ,2 ]
Guerrero, Anthony J. [1 ,2 ]
Bouwmeester, Dave [1 ,2 ]
Fygenson, Deborah Kuchnir [1 ,2 ,3 ]
机构
[1] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA
[2] Univ Calif Santa Barbara, Calif Nanosyst Inst, Santa Barbara, CA 93106 USA
[3] Univ Calif Santa Barbara, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA
关键词
D O I
10.1002/adma.200702380
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
DNA-bound silver nanoemitters reside in single-stranded regions of the host DNA. Their fluorescence is sensitive to both the DNA base sequence and its secondary structure. Fluorescence from individual emitters hosted by DNA "hairpins", which are suitable for incorporation into DNA scaffolds, is detectable using standard epifluorescence techniques.
引用
收藏
页码:279 / +
页数:6
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