Axonal injury, a neglected cause of CNS damage in bacterial meningitis

被引：38

作者：

Nau, R

Gerber, J

Bunkowski, S

Brück, W

机构：

[1] Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany

[2] Univ Gottingen, Dept Neuropathol, D-3400 Gottingen, Germany

来源：

NEUROLOGY | 2004年 / 62卷 / 03期

关键词：

D O I：

10.1212/01.WNL.0000106826.82670.30

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The contribution of axonal injury to CNS damage in bacterial meningitis was studied by histology and immunohistochemistry for amyloid-beta precursor protein in humans and experimental rabbits. Axonal injury in the white matter caused predominantly but not exclusively by ischemia was detected in all autopsy cases (n = 5) and in 11 of 15 brains of rabbits 18 to 24 hours after intracisternal infection with Streptococcus pneumoniae. This suggests a substantial contribution of axonal pathology to neurologic sequelae after bacterial meningitis.

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页码：509 / 511

页数：3

相关论文

共 10 条

[1] Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases [J].

Aboul-Enein, F ;

Rauschka, H ;

Kornek, B ;

Stadelmann, C ;

Stefferl, A ;

Brück, W ;

Lucchinetti, C ;

Schmidbauer, M ;

Jellinger, K ;

Lassmann, H .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2003, 62 (01) :25-33

[2]

ADAMS R D, 1948, Arch Pediatr, V65, ppassim

[3]

Adams RA, 1997, Principles of neurology, V6th

[4] Acute axonal injury in multiple sclerosis -: Correlation with demyelination and inflammation [J].

Bitsch, A ;

Schuchardt, J ;

Bunkowski, S ;

Kuhlmann, T ;

Brück, W .

BRAIN, 2000, 123 :1174-1183

[5] Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats [J].

Bramlett, HM ;

Kraydieh, S ;

Green, EJ ;

Dietrich, WD .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1997, 56 (10) :1132-1141

[6] Hypoglycaemia is a cause of axonal injury [J].

Dolinak, D ;

Smith, C ;

Graham, DI .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2000, 26 (05) :448-453

[7] Axonal damage: a key predictor of outcome in human CNS diseases [J].

Medana, IM ;

Esiri, MM .

BRAIN, 2003, 126 :515-530

[8] Neuronal injury in bacterial meningitis:: mechanisms and implications for therapy [J].

Nau, R ;

Brück, W .

TRENDS IN NEUROSCIENCES, 2002, 25 (01) :38-45

[9] CEREBROVASCULAR COMPLICATIONS OF BACTERIAL-MENINGITIS IN ADULTS [J].

PFISTER, HW ;

BORASIO, GD ;

DIRNAGL, U ;

BAUER, M ;

EINHAUPL, KM .

NEUROLOGY, 1992, 42 (08) :1497-1504

[10] Axonal transection in the lesions of multiple sclerosis [J].

Trapp, BD ;

Peterson, J ;

Ransohoff, RM ;

Rudick, R ;

Mörk, S ;

Bö, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (05) :278-285