Moving protein heads for breakdown

被引：19

作者：

Scheffner, M ^{[1
]}

机构：

[1] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

来源：

NATURE | 1999年 / 398卷 / 6723期

关键词：

D O I：

10.1038/18105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To be broken down, p27(Kip1) - a protein that regulates the cell cycle - must be exported from the nucleus. This unexpected step could turn out to be a general way to regulate the turnover of many nuclear proteins.

引用

页码：103 / 104

页数：2

共 9 条

[1] A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
Claret, FX
Hibi, M
Dhut, S
Toda, T
Karin, M
[J]. NATURE, 1996, 383 (6599) : 453 - 457
[2] Glycogen synthase kinase 3β regulates cyclin D1 proteolysis and subcellular localization
Diehl, JA
Cheng, MG
Roussel, MF
Sherr, CJ
[J]. GENES & DEVELOPMENT, 1998, 12 (22) : 3499 - 3511
[3] Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
Freedman, DA
Levine, AJ
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (12) : 7288 - 7293
[4] The ubiquitin system
Hershko, A
Ciechanover, A
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 425 - 479
[5] The PCI domain: a common theme in three multiprotein complexes
Hofmann, K
Bucher, P
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (06) : 204 - 205
[6] ROLE OF THE UBIQUITIN-PROTEASOME PATHWAY IN REGULATING ABUNDANCE OF THE CYCLIN-DEPENDENT KINASE INHIBITOR P27
PAGANO, M
TAM, SW
THEODORAS, AM
BEERROMERO, P
DELSAL, G
CHAU, V
YEW, PR
DRAETTA, GF
ROLFE, M
[J]. SCIENCE, 1995, 269 (5224) : 682 - 685
[7] Cyclin E-CDK2 is a regulator of p27(Kip1)
Sheaff, RJ
Groudine, M
Gordon, M
Roberts, JM
Clurman, BE
[J]. GENES & DEVELOPMENT, 1997, 11 (11) : 1464 - 1478
[8] Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
Tomoda, K
Kubota, Y
Kato, J
[J]. NATURE, 1999, 398 (6723) : 160 - 165
[9] Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27(Kip1)
Vlach, J
Hennecke, S
Amati, B
[J]. EMBO JOURNAL, 1997, 16 (17) : 5334 - 5344

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