Dietary Flavonoids Added to Pharmacological Antihypertensive Therapy are Effective in Improving Blood Pressure

被引:34
作者
de Jesus Romero-Prado, Marina Maria [1 ,2 ]
Aaron Curiel-Beltran, Jesus [2 ,3 ]
Viviana Miramontes-Espino, Maria [1 ,2 ]
German Cardona-Munoz, Ernesto [1 ]
Rios-Arellano, Angeles [4 ]
Balam-Salazar, Lol-Be [5 ]
机构
[1] Univ Ctr Hlth Sci CUCS, Dept Physiol, INTEC, Guadalajara, Jalisco, Mexico
[2] Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico
[3] Coast Univ Ctr CUCosta, Dept Med Sci, Guadalajara, Jalisco, Mexico
[4] Reg Hosp 45, Mexican Inst Hlth Secur, Cardiol Serv, Guadalajara, Jalisco, Mexico
[5] IMSS, Clin Anal Lab, Merida, Yucatan, Mexico
关键词
LDL OXIDATIVE SUSCEPTIBILITY; GREEN TEA; COCOA POWDER; INTESTINAL-ABSORPTION; MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION; PHOSPHOLIPASE A(2); ANGIOTENSIN-II; DARK CHOCOLATE; NITRIC-OXIDE;
D O I
10.1111/bcpt.12360
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
Epidemiological studies have suggested that the daily intake of flavonoids is associated with a decreased risk of developing cardiovascular disease. Our purpose was to evaluate the effect of the addition of dietary flavonoids (DF) to antihypertensive treatment (AHT), based on telmisartan (Tms) or captopril (Cpr), on blood pressure (BP), body mass index (BMI), waist/hip ratio, leptin, lipid profile and inflammation in hypertensive young patients. An open-label, randomized, controlled trial was performed among 79 patients aged 20-55 years with grade I or grade II systemic arterial hypertension. The subjects were assigned to one of four groups for AHT plus DF during 6 months: Cpr (n = 14), Cpr + DF (n = 19), Tms (n = 25) and Tms + DF (n = 21). DF consisted of dark chocolate, dehydrated red apple and green tea in an infusion to obtain a daily dose of 425.8 +/- 13.9 mg epicatechin equivalents. The BP and anthropometric parameters were measured every 2 weeks. Lipid profile, leptin and hsCRP were determined by standard methods. The combination AHT-DF produced an additional and significant reduction in (i) SBP/DBP of -5/-4 mmHg, being -7/-5 for Cpr + DF and -4/-3 for Tms + DF; (ii) triglyceride levels (-30.6%) versus AHT alone (-9.6%); and (iii) leptin: Cpr + DF versus Tms + DF (p < 0.005). Finally, C-reactive protein plasma levels were reduced significantly in all groups independently of the applied treatment. We conclude that the addition of flavonoids to pharmacological antihypertensive therapy shows additional benefits on BP, lipid profile, leptin, obesity and inflammation.
引用
收藏
页码:57 / 64
页数:8
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