COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas

被引:182
作者
Armentano, Maria
Chou, Shen-Ju
Tomassy, Giulio Srubek
Leingaertner, Axel
O'Leary, Dennis D. M.
Studer, Michele
机构
[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
[2] TIGEM, Dev Disorders Program, I-80131 Naples, Italy
关键词
D O I
10.1038/nn1958
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital cortex that form sensory areas, and the lowest expression was observed in frontal cortex that includes motor areas. Cortical deletion of COUP-TFI resulted in massive expansion of frontal areas, including motor, to occupy most of neocortex, paralleled by marked compression of sensory areas to caudal occipital cortex. These area patterning changes are preceded and paralleled by corresponding changes in molecular markers of area identity and altered axonal projections to maintain patterned area-specific input and output connections. We conclude that COUP-TFI is required for balancing patterning of neocortex into frontal/motor and sensory areas by acting in its expression domain to repress frontal/motor area identities and to specify sensory area identities.
引用
收藏
页码:1277 / 1286
页数:10
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