CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes

被引：22

作者：

Benet, Zachary L. ^{[1
]}

Marthi, Matangi ^{[1
]}

Ke, Fang ^{[1
]}

Wu, Rita ^{[1
]}

Turner, Jackson S. ^{[1
]}

Gabayre, Jahan B. ^{[1
]}

Ivanitskiy, Michael I. ^{[1
]}

Sethi, Sahil S. ^{[1
]}

Grigorova, Irina L. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

germinal centers; follicular regulatory T cells (Tfr); CCL3/MIP1-alpha; 2-photon imaging; follicular helper T cells; MACROPHAGE INFLAMMATORY PROTEIN-1; CHEMOKINE PRODUCTION; TRANSGENIC MICE; RESPONSES; HELPER; SUPPRESSION; EXPRESSION; ANTIGEN; AUTOIMMUNITY; MIP-1-ALPHA;

D O I：

10.3389/fimmu.2018.02044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. Two-photon imaging revealed that B cells-intrinsic production of CCL3 promotes their probing by follicular regulatory T cells (Tfr) within GCs of murine lymph nodes. Overall this study suggests that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo.

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