Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia

被引:34
作者
Haenschel, Corinna [1 ]
Linden, David [1 ]
机构
[1] Bangor Univ, Wales Inst Cognit Neurosci, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales
关键词
Working Memory; Encoding; Schizophrenia; EEG; Oscillations; Synchrony; Neuropharmacology; SHORT-TERM-MEMORY; PARVALBUMIN-POSITIVE INTERNEURONS; DORSOLATERAL PREFRONTAL CORTEX; GAMMA-BAND RESPONSE; MISMATCH NEGATIVITY POTENTIALS; COGNITIVE REMEDIATION THERAPY; INTERVAL CORTICAL INHIBITION; RANDOMIZED CONTROLLED-TRIAL; VISUAL PROCESSING DEFICITS; AUDITORY SENSORY MEMORY;
D O I
10.1016/j.bbr.2010.08.045
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
This review brings together two strands of investigation in the neuropsychology and neurophysiology of schizophrenia that have been particularly productive over the last 20 years. We review the literature on working memory deficits, particularly in the visual domain, and changes in oscillatory neural activity as measured with electroencephalography (EEG) and magnetoencephalography (MEG). We argue that recent results suggest a link between these two phenomena, in that altered oscillations underlie some of the working memory deficits. We furthermore argue that early sensory mechanisms contribute more to working memory (and other) deficits than previously thought. The final part of our review suggests links between working memory, oscillations, and their alterations in schizophrenia and the dopamine, GABA, glutamate and acetylcholine system. These links have already resulted in the development of new remediation strategies, which have some translational potential. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:481 / 495
页数:15
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