Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescents

被引：24

作者：

Axelson, DA ^{[1
]}

Perel, JM ^{[1
]}

Birmaher, B ^{[1
]}

Rudolph, G ^{[1
]}

Nuss, S ^{[1
]}

Yurasits, L ^{[1
]}

Bridge, J ^{[1
]}

Brent, DA ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2005年 / 162卷 / 04期

关键词：

D O I：

10.1176/appi.ajp.162.4.802

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The authors examined platelet serotonin reuptake inhibition and response to selective serotonin reuptake inhibitor (SSRI) treatment in depressed adolescents. Method: Twenty-three depressed adolescents participating in pharmacokinetic studies of SSRIs had platelet serotonin reuptake measured before and after 14 - 28 days of treatment. The Clinical Global Impression (CGI) improvement rating was determined on the basis of all clinical information and was performed blind to the platelet data. Results: Improvement in depressive symptoms as rated with the CGI improvement subscale was significantly associated with the percentage change in platelet serotonin reuptake inhibition from pre- to posttreatment. Improvement in depression was also associated with absolute decrease in platelet serotonin reuptake when adjusted for the magnitude of baseline reuptake. Conclusions: Platelet serotonin reuptake inhibition may be an appropriate surrogate biological marker for the pharmacodynamic activity of SSRIs in depressed adolescents.

引用

页码：802 / 804

页数：3

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