Molecular and cellular biomarkers for angiogenesis in clinical oncology

被引：67

作者：

Bertolini, Francesco ^{[1
]}

Mancuso, Patrizia

Shaked, Yuval

Kerbel, Robert S.

机构：

[1] European Inst Oncol, Dept Med, Div Hematol Oncol, I-20141 Milan, Italy

[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 19-20期

关键词：

D O I：

10.1016/j.drudis.2007.08.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Medical oncologists are increasingly using anti-angiogenic drugs, but identifying the best-suited drug and the optimal dosage and schedule for treatment of patients remain challenging issues. Circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) are modulated in a variety of diseases including cancer, and are promising surrogate biomarkers in oncology. Molecular surrogate markers, on the other hand, are more scanty at the present time, because the identification of truly endothelial cell-restricted genes and/or antigens is complex. Here, we discuss the biological and technical facets of the search and validation of new biomarkers for angiogenesis.

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页码：806 / 812

页数：7

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