Further application of an N-Ar axially chiral mimetic-type ligand: Asymmetric Grignard cross-coupling reaction

被引：24

作者：

Horibe, H

Kazuta, K

Kotoku, M

Kondo, K

Okuno, H

Murakami, Y

Aoyama, T

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

SYNLETT | 2003年 / 13期

关键词：

N-Ar axis; chiral mimetics; optically active ligand; Grignard cross-coupling; asymmetric Kumada-Corriu reaction;

D O I：

10.1055/s-2003-41485

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel chiral ligand mimicking N-Ar axial chirality, (S)-N-[2-(diphenylphosphanyl)naphthalen-1-yl]-2-(piperidinylmethyl)piperidine, was found to exhibit good enantio selectivity (up to 80% ee) in the asymmetric cross-coupling reaction of 1-phenylethylmagnesium chloride with beta-bromostyrene derivatives. Additionally, this type ligand is appealing, because it allows the synthesis of a wide variety of analogues.

引用

页码：2047 / 2051

页数：5

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