Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori

被引：14

作者：

Maruta, F

Sugiyama, A

Ishida, K

Ikeno, T

Murakami, M

Kawasaki, S

Ota, H

Tatematsu, M

Katsuyama, T

机构：

[1] Shinshu Univ, Sch Med, Dept Surg 1, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ Hosp, Cent Clin Labs, Matsumoto, Nagano 3908621, Japan

[3] Aichi Canc Ctr, Res Inst, Pathol Lab, Chikusa Ku, Nagoya, Aichi 4640021, Japan

[4] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Nagano 3908621, Japan

来源：

CANCER LETTERS | 2000年 / 160卷 / 01期

关键词：

carcinogenesis; gastric cancer; Helicobacter pylori; Mongolian gerbil; N-methyl-N-nitrosourea; stomach;

D O I：

10.1016/S0304-3835(00)00571-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given MNU at 24 weeks, and another at 1 week, after H. pylori inoculation. The other groups received only MNU. Stomachs were excised for histological examination 20 weeks after completing the MNU treatment. Carcinomas arose only in animals given MNU 1 week after H. pylori inoculation. In the relationship between H. pylori and gastric carcinogenesis. H. pylori is a promoter rather than an initiator, and other environ mental factors (the timing of MNU administration) play important roles, (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 105

页数：7

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