Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites

被引：87

作者：

Kawamura, A

Koshida, S

Hijikata, H

Sakaguchi, T

Kondoh, H

Takada, S ^{[1
]}

机构：

[1] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan

[2] Grad Univ Adv Studies, Dept Mol Biomech, Okazaki, Aichi 4448787, Japan

[3] Japan Sci & Technol Corp, Kinki Invent Ctr, ERATO, Kondoh Differentiat Signaling Project,SORST Progr, Kyoto 6068305, Japan

[4] Univ Calif San Francisco, Dept Biochem & Biophys, Program Dev Biol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Biochem & Biophys, Program Genet & Human Genet, San Francisco, CA 94143 USA

[6] Osaka Univ, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 10期

关键词：

somite segmentation; FGF signaling cyclic gene expression; hairy/Espl; negative feedback loop; zebrafish;

D O I：

10.1101/gad.1291205

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.

引用

页码：1156 / 1161

页数：6

共 32 条

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