Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex

被引：23

作者：

Crayton, JW

Joshi, I

Gulati, A

Arora, RC

Wolf, WA

机构：

[1] UNIV ILLINOIS, DEPT PHARMACOL, CHICAGO, IL USA

[2] LOYOLA UNIV, STRITCH SCH MED, DEPT PHARMACOL, MAYWOOD, IL 60153 USA

来源：

BRAIN RESEARCH | 1996年 / 728卷 / 02期

关键词：

serotonin; receptor; transporter; cortex; rat;

D O I：

10.1016/S0006-8993(96)00189-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of corticosterone (1 mg/kg per day for 7 days) on serotonin 5-HT1A, 5-HT2A, 5-HT uptake sites, and alpha(2)-adrenergic receptor sites were measured. Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (B-max = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively). No significant differences were found in other measures. It is possible that corticosteroids exert some of their behavioral effects via regulation of 5-HT1A sites in frontal cortex.

引用

收藏

页码：260 / 262

页数：3

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