Biosynthesis of polyesters in bacteria and recombinant organisms

被引：32

作者：

Steinbuchel, A ^{[1
]}

Fuchtenbusch, B ^{[1
]}

Gorenflo, V ^{[1
]}

Hein, S ^{[1
]}

Jossek, R ^{[1
]}

Langenbach, S ^{[1
]}

Rehm, BHA ^{[1
]}

机构：

[1] Univ Munster, Inst Mikrobiol, D-48149 Munster, Germany

来源：

POLYMER DEGRADATION AND STABILITY | 1998年 / 59卷 / 1-3期

关键词：

D O I：

10.1016/S0141-3910(97)00173-0

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Many bacteria are able to synthesize polyesters of hydroxyalkanoic acids (PHA), which occur as insoluble cytoplasmic inclusions in the cell and can contribute significantly to the cellular dry matter. More than 100 different hydroxyalkanoic acids have been detected as constituents in PHA. This article summarizes strategies and possibilities to obtain these biodegradable and thermoplastic/elastomeric polymers by fermentation of wild-type bacteria as well as of mutants and recombinant strains from renewable resources, waste substrates or special precursor substrates. In addition, in vitro biosynthesis of PHA employing the purified polymerizing enzyme (PHA synthase) is described. Throughout analysis and cloning of the bacterial PHA biosynthesis genes enabled scientists to also establish this pathway in non-PHA producing eukaryotic organisms such as yeast, plants and animals. This will allow new processes for cheap and economic production of PHA. (C) 1998 Elsevier Science Limited. All rights reserved.

引用

页码：177 / 182

页数：6

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