Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in blacks and whites - The Bogalusa Heart Study

被引:84
作者
Chen, Wei [1 ]
Srinivasan, Sathanur R. [1 ]
Li, Shengxu [1 ]
Xu, Jihua [1 ]
Berenson, Gerald S. [1 ]
机构
[1] Tulane Univ, Tulane Ctr Cardiovasc Hlth, New Orleans, LA 70112 USA
关键词
insulin resistance; longitudinal studies; metabolic syndrome X; obesity;
D O I
10.1093/aje/kwm105
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Clustering of long-term rates of change in metabolic syndrome variables (body mass index, homeostasis model assessment of insulin resistance, ratio of triglycerides to high-density lipoprotein cholesterol, and mean arterial pressure) from childhood to adulthood was evaluated longitudinally (1982-2003) in a cohort of 389 Blacks and 631 Whites who were examined 3-6 times both as children (ages 4-17 years) and as adults (ages 18-38 years) over an average of 16 years (3,874 observations). The incremental area under the growth curve was used as a measure of long-term rates of change in risk variables since childhood. Intraclass correlations, a measure of the degree of clustering, among the four variables were significant (p < 0.001) for childhood, adulthood, and incremental area values and were higher in adulthood than in childhood. Blacks showed a higher degree of clustering of long-term rates of change in risk variables than did Whites. Adjustment for body mass index reduced the degree of clustering by approximately 50%. These results show that metabolic syndrome variables coexist in terms not only of their levels in childhood and adulthood but also of long-term rates of change. Obesity is of critical importance in the development of metabolic syndrome, and its prevention beginning in childhood needs to be addressed.
引用
收藏
页码:527 / 533
页数:7
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