Matrix-assisted laser desorption chemical ionization with reagent ion generation directly from a liquid matrix

被引：19

作者：

Breuker, K ^{[1
]}

Knochenmuss, R ^{[1
]}

Zenobi, R ^{[1
]}

机构：

[1] ETH Zurich, Dept Chem, CH-8092 Zurich, Switzerland

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 1998年 / 176卷 / 1-2期

关键词：

chemical ionization; two-phase MALDI;

D O I：

10.1016/S1387-3806(98)14015-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Highly concentrated aqueous salt solutions were tested for their ability to serve as a reagent anion source for matrix-assisted laser desorption/chemical ionization (MALD/Cl). It was found that tetrabutylammonium salt/silicon binary matrices yielded abundant deprotonated analyte signals. Moreover, controlled, specific fragmentation of carbohydrates, nucleotides, and peptides was observed, providing useful structural information. The degree of fragmentation was found to depend on the proton affinity of the reagent anion used. (Int J Mass Spectrom 176 (1998) 149-159) (C) 1998 Elsevier Science B.V.

引用

页码：149 / 159

页数：11

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