Immunogenetics and genomics

被引：51

作者：

Hill, AVS ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

LANCET | 2001年 / 357卷 / 9273期

关键词：

D O I：

10.1016/S0140-6736(00)05117-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunogenetic analysis of disease susceptibility has been encouraged by the identification of strong HLA associations with several diseases of uncertain cause. Weaker HLA associations exist with a large number of infectious and noninfectious diseases and the mechanisms of these effects are beginning to be uncovered. Extensive analyses of non-HLA immunogenetic variants have also been undertaken and associations with a variety of genes identified. Genetic linkage analysis of multicase families has recently identified new major susceptibility loci for a few immunologically determined common diseases. However, the greatest potential for the future lies in genome-wide searches for susceptibility genes that individually might have quite modest effects but cumulatively have a large Impact on individual risk. This new era of Immunogenomics promises to provide key insights into disease pathogenesis and Identify multiple molecular targets for intervention strategies.

引用

页码：2037 / 2041

页数：5

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