Oncogenic breakdowns in endocytic adaptor proteins

被引：14

作者：

Crosetto, N ^{[1
]}

Tikkanen, R ^{[1
]}

Dikic, I ^{[1
]}

机构：

[1] Geothe Univ Hosp, Inst Biochem 2, D-60590 Frankfurt, Germany

来源：

FEBS LETTERS | 2005年 / 579卷 / 15期

关键词：

signal transduction; endocytosis; molecular adaptors; oncogenesis; ubiquitination;

D O I：

10.1016/j.febslet.2005.03.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endocytosis is a versatile tool to regulate the intensity, localization, half-life and function of signaling complexes (signalosomes) that form in cells upon binding of growth factors, cytokines and morphogens to their cognate receptors. Endocytic adaptors are non-catalytic proteins that assemble effectors and structural components of the endocytic machinery around the trafficking cargo and serve as scaffolds for signalosomes, which in turn modify their location and activity by various post-translational modifications. We discuss how breakdowns in the function of endocytic adaptors might facilitate impairment of tissue homeostasis and consequent tumor development. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3231 / 3238

页数：8

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