DNA polymerases in adaptive immunity

被引:52
作者
Weill, Jean-Claude [1 ]
Reynaud, Claude-Agnes [1 ]
机构
[1] Univ Paris 05, INSERM,Fac Med, U 783, Site Necker Enfants Malades, Paris 15, France
关键词
D O I
10.1038/nri2281
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key genetic loci in each lymphoid cell. These modifications proceed through the action of lymphoid-specific proteins acting together with the general DNA-repair machinery of the cell. Strikingly, these general mechanisms are usually diverted from their normal functions, being used in rather atypical ways in order to privilege diversity over accuracy. In this Review, we focus on the contribution of a set of DNA polymerases discovered in the past decade to these unique DNA transactions.
引用
收藏
页码:302 / 312
页数:11
相关论文
共 121 条
[1]   Two novel human and mouse DNA polymerases of the polX family [J].
Aoufouchi, S ;
Flatter, E ;
Dahan, A ;
Faili, A ;
Bertocci, B ;
Storck, S ;
Delbos, F ;
Cocea, L ;
Gupta, N ;
Weill, JC ;
Reynaud, CA .
NUCLEIC ACIDS RESEARCH, 2000, 28 (18) :3684-3693
[2]   Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate [J].
Arakawa, H ;
Saribasak, H ;
Buerstedde, JM .
PLOS BIOLOGY, 2004, 2 (07) :967-974
[3]   Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion [J].
Arakawa, H ;
Hauschild, J ;
Buerstedde, JM .
SCIENCE, 2002, 295 (5558) :1301-1306
[4]   A role for PCNA ubiquitination in immunoglobulin hypermutation [J].
Arakawa, Hiroshi ;
Moldovan, George-Lucian ;
Saribasak, Huseyin ;
Saribasak, Nesibe Nur ;
Jentsch, Stefan ;
Buerstedde, Jean-Marie .
PLOS BIOLOGY, 2006, 4 (11) :1947-1956
[5]   Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase [J].
Avkin, S ;
Adar, S ;
Blander, G ;
Livneh, Z .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3764-3769
[6]   Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice [J].
Bardwell, PD ;
Woo, CJ ;
Wei, KC ;
Li, ZQ ;
Martin, A ;
Sack, SZ ;
Parris, T ;
Edelmann, W ;
Scharff, MD .
NATURE IMMUNOLOGY, 2004, 5 (02) :224-229
[7]   Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro [J].
Bemark, M ;
Khamlichi, AA ;
Davies, SL ;
Neuberger, MS .
CURRENT BIOLOGY, 2000, 10 (19) :1213-1216
[8]   Immunoglobulin κ light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu [J].
Bertocci, B ;
De Smet, A ;
Berek, C ;
Weill, JC ;
Reynaud, CA .
IMMUNITY, 2003, 19 (02) :203-211
[9]   Nonoverlapping functions of DNA polymerases Mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo [J].
Bertocci, Barbara ;
De Smet, Annie ;
Weill, Jean-Claude ;
Reynaud, Claude-Agnes .
IMMUNITY, 2006, 25 (01) :31-41
[10]   Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].
Bienko, M ;
Green, CM ;
Crosetto, N ;
Rudolf, F ;
Zapart, G ;
Coull, B ;
Kannouche, P ;
Wider, G ;
Peter, M ;
Lehmann, AR ;
Hofmann, K ;
Dikic, I .
SCIENCE, 2005, 310 (5755) :1821-1824