The DDAH/ADMA/NOS pathway

被引：264

作者：

Tran, CTL ^{[1
]}

Leiper, JM ^{[1
]}

Vallance, P ^{[1
]}

机构：

[1] UCL, Div Med, BHF Labs, Ctr Clin Pharmacol & Therapeut, London WC1E 6JJ, England

来源：

ATHEROSCLEROSIS SUPPLEMENTS | 2003年 / 4卷 / 04期

关键词：

asymmetric dimethylarginine; nitric oxide; dimethylarginine dimethylaminohydrolase; cardiovascular disease;

D O I：

10.1016/S1567-5688(03)00032-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

An increasing number of reports in the literature indicate that endogenously produced inhibitors of nitric oxide synthase (NOS), particularly asymmetric dimethylarginine (ADMA) regulate nitric oxide generation in numerous disease states. Two dimethylarginine dimethylaminobydrolase (DDAH) enzymes metabolise ADMA. We and others have postulated that activity of DDAH is a key determinant of ADMA levels in vivo. This review summarises recent advances in the regulation and function of DDAH enzymes and its role in the regulation of nitric oxide generation. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：33 / 40

页数：8

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