Role of mast cells in acupuncture effect: A pilot study

被引：144

作者：

Zhang, Di ^{[1
]}

Ding, Guanghong ^{[1
]}

Shen, Xueyong ^{[2
]}

Yao, Wei ^{[1
]}

Zhang, Zhiying ^{[3
]}

Zhang, Yuqing ^{[1
]}

Lin, Jun ^{[1
]}

Gu, Quanbao ^{[4
]}

机构：

[1] Fudan Univ, Dept Mech & Engn Sci, Shanghai Res Ctr Acupuncture & Meridians, Shanghai 200433, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Coll Acupuncture Moxibust, Shanghai, Peoples R China

[3] Second Mil Med Univ, Dept Anat, Shanghai, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Cell Biol, Shanghai, Peoples R China

来源：

EXPLORE-THE JOURNAL OF SCIENCE AND HEALING | 2008年 / 4卷 / 03期

关键词：

acupoint; mast cells; DSCG; analgesia; degranulation ratio;

D O I：

10.1016/j.explore.2008.02.002

中图分类号：

R [医药、卫生];

学科分类号：

10 [医学];

摘要：

To better understand the therapeutic effectiveness of acupuncture, questions about the underlying mechanisms need to be addressed. Here we describe the impact of manual stimulation by an acupuncture needle of zusanli (stomach 36 [ST36]) on analgesia in rats. The analgesic effect was more pronounced after stimulation of ST36 than after stimulation of a sham point near the acupuncture point. At the same time, we determined in tissue slices the density of mast cells in the acupuncture points and nearby points, as well as the degree of degranulation before and after stimulation. We found that the density of mast cells from the ST36 of rats was higher than that from a nearby sham point. In addition, acupuncture resulted in a remarkable increase in degranulation of the mast cells. Pretreatment of the acupuncture point with disodium chromoglycate not only counteracted the phenomenon of degranulation but also reduced analgesic effect of acupuncture. Our experiments on inhibition of degranulation of mast cells in tissue from acupuncture points demonstrates the possible role of mast cells in acupuncture effects.

引用

页码：170 / 177

页数：8

共 32 条

[1]

THYMUS DEPENDENCE OF CONNECTIVE-TISSUE MAST-CELLS - A QUANTITATIVE CYTOFLUOROMETRIC STUDY OF THE GROWTH OF PERITONEAL MAST-CELLS IN NORMAL AND ATHYMIC RATS [J].