Association study of the GAB2 gene with the risk of developing Alzheimer's disease

被引：31

作者：

Chapuis, Julien ^{[2
]}

Hannequin, Didier ^{[1
]}

Pasquier, Florence ^{[3
]}

Bentham, Peter ^{[4
]}

Brice, Alexis ^{[5
]}

Leber, Isabelle ^{[5
]}

Frebourg, Thierry ^{[1
]}

Deleuze, Jean-Francois ^{[6
]}

Cousin, Emmanuelle ^{[6
]}

Thaker, Uma ^{[7
]}

Amouyel, Philippe ^{[2
]}

Mann, David ^{[7
]}

Lendon, Corinne ^{[8
]}

Campion, Dominique ^{[1
]}

Lambert, Jean-Charles ^{[2
]}

机构：

[1] Fac Med, INSERM, U614, IFRMP, F-76000 Rouen, France

[2] Univ Lille 2, INSERM, U744, Inst Pasteur Lille, Lille, France

[3] Univ Hosp Lille, Memory Clin, Dept Neurol, EA 2691, Lille, France

[4] Queen Elizabeth Psychiat Hosp, Dept Psychiat, Birmingham B15 2QZ, W Midlands, England

[5] Hop La Pitie Salpetriere, INSERM, U 679, F-75013 Paris, France

[6] Evry Genet Ctr, Sanofi Aventis, F-91057 Evry, France

[7] Univ Manchester, Hope Hosp, Greater Manchester Neurosci Ctr, Manchester, Lancs, England

[8] Queensland Inst Med Res, Mol Psychiat Grp, Brisbane, Qld 4006, Australia

来源：

NEUROBIOLOGY OF DISEASE | 2008年 / 30卷 / 01期

关键词：

Alzheimer; GAB2; APOE; polymorphism;

D O I：

10.1016/j.nbd.2007.12.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE epsilon 4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT + TT) = 1.3, 95% CI 1.0-1.6, p=0.09) and the G allele frequency (OR=13, 95%CI 1.0-1.6, p=0.05) in e4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：103 / 106

页数：4

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