Osteoarthritis subpopulations and implications for clinical trial design

被引：72

作者：

Bierma-Zeinstra, Sita M. A. ^{[1
,2
]}

Verhagen, Arianne P. ^{[1
,3
]}

机构：

[1] Univ Med Ctr Erasmus MC, Dept Gen Practice, NL-3000 CA Rotterdam, Netherlands

[2] Univ Med Ctr Erasmus MC, Dept Orthoped, NL-3000 CA Rotterdam, Netherlands

[3] Avans Univ Appl Sci, Sch Hlth, NL-4800 RA Breda, Netherlands

来源：

ARTHRITIS RESEARCH & THERAPY | 2011年 / 13卷 / 02期

关键词：

LOW-BACK-PAIN; KNEE OSTEOARTHRITIS; HIP OSTEOARTHRITIS; SUBGROUP ANALYSES; RADIOGRAPHIC OSTEOARTHRITIS; FUNCTIONAL POLYMORPHISM; PROGNOSTIC-FACTORS; ASSOCIATION; PROGRESSION; HAND;

D O I：

10.1186/ar3299

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Treatment guidelines for osteoarthritis have stressed the need for research on clinical predictors of response to different treatments. However, identifying such clinical predictors of response is less easy than it seems, and there is not a given classification of osteoarthritis subpopulations. This review article highlights the key methodical issues when analyzing and designing clinical studies to detect important subgroups with respect to treatment effect. In addition, we discuss the main osteoarthritis subpopulations and give examples of how specific treatment effects in these subpopulations have been assessed.

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