Intestinal development and differentiation

被引：304

作者：

Noah, Taeko K. ^{[1
]}

Donahue, Bridgitte ^{[2
]}

Shroyer, Noah F. ^{[1
,2
,3
]}

机构：

[1] Cincinnati Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Med Ctr, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Canc & Cell Biol Grad Program, Cincinnati, OH USA

[3] Cincinnati Childrens Hosp, Div Dev Biol, Med Ctr, Cincinnati, OH 45229 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 19期

关键词：

Intestine; Development; Differentiation; Epithelium; Endoderm; Villus; Crypt; Goblet cell; Paneth; Enteroendocrine; Enterocyte; Colonocyte; Tuft cell; Stem cell; PANETH CELL-DIFFERENTIATION; ATONAL HOMOLOG 1; BETA-CATENIN; EPITHELIAL-CELLS; GASTROINTESTINAL-TRACT; MOUSE INTESTINE; TERMINAL DIFFERENTIATION; ENTEROENDOCRINE CELLS; PROGENITOR CELLS; PEYERS-PATCHES;

D O I：

10.1016/j.yexcr.2011.09.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this review, we present an overview of intestinal development and cellular differentiation of the intestinal epithelium. The review is separated into two sections: Section one summarizes organogenesis of the small and large intestines, including endoderm and gut tube formation in early embryogenesis, villus morphogenesis, and crypt formation. Section two reviews cell fate specification and differentiation of each cell type within the intestinal epithelium. Growth factor and transcriptional networks that regulate these developmental processes are summarized. (C) 2011 Elsevier Inc. All rights reserved.

引用

收藏

页码：2702 / 2710

页数：9

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