Polymorphisms of interleukin-1 gene complex, IL6 and tumour necrosis factor genes in chronic idiopathic neutropenia of adults

被引：8

作者：

Addas-Carvalho, M

de Paula, EV

Lima, CSP

Saad, STO

机构：

[1] Univ Estadual Campinas, Hemoctr, BR-13081970 Campinas, SP, Brazil

[2] Univ Estadual Campinas, UNICAMP, Haematol & Hemotherapy Ctr, BR-13081970 Campinas, SP, Brazil

[3] Univ Estadual Campinas, UNICAMP, Dept Internal Med, BR-13081970 Campinas, SP, Brazil

来源：

ANNALS OF HEMATOLOGY | 2005年 / 84卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

chronic neutropenia; cytokine; IL1B; IL6; TNF;

D O I：

10.1007/s00277-005-1066-9

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained" decrease in the number of circulating neutrophils. Serum inflammatory cytokines and chemokines are increased in CINA. In addition, cytokines gene polymorphisms are associated with increased levels of respective products and related with inflammatory diseases. The aim of the present study was to investigate the association of polymorphisms of IL1B-511C/T and +3953C/T, IL1RN intron 2, IL6-174G/C and TNF-308G/A genes with CINA. We analysed 29 CINA and controls by polymerase chain reaction and restriction fragment length polymorphism. Statistical analyses were performed using chi(2) test, and the Hardy-Weinberg equilibrium (HWE) was investigated. All alleles analysed were in HWE in both populations. Similar frequencies of IL1B-511C/T, IL1B+3953C/T, IL1RN, IL6-174G/C and TNF-308G/A genotypes were observed in CINA and controls. These results suggest that cytokine polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of CINA and were not responsible for the increased cytokine in CINA patients.

引用

页码：709 / 714

页数：6

共 27 条

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