CD133 as a Marker for Regulation and Potential for Targeted Therapies in Glioblastoma Multiforme

被引：40

作者：

Choy, Winward ^{[1
]}

Nagasawa, Daniel T. ^{[1
]}

Trang, Andy ^{[1
]}

Thill, Kimberly ^{[1
]}

Spasic, Marko ^{[1
]}

Yang, Isaac ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Jonsson Comprehens Canc Ctr,Malignant Brain Tumor, Los Angeles, CA 90095 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2012年 / 23卷 / 03期

关键词：

Cancer stem cell; CD133; Glioblastoma; Glioma; CANCER STEM-CELLS; TUMOR-INITIATING CELLS; PLASMA-MEMBRANE PROTRUSIONS; HYPOXIA-INDUCIBLE FACTORS; HUMAN HEMATOPOIETIC STEM; PHASE-II TRIAL; ENDOTHELIAL-CELLS; GLIOMA-CELLS; PROGENITOR CELLS; IN-VITRO;

D O I：

10.1016/j.nec.2012.04.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The CD133 epitope has been identified as a tumor marker for the purification of a subpopulation of glioblastoma multiforme (GBM) cells demonstrating cancer stem cell phenotypes. Isolated tumorsphere-forming CD133(+) GBM cells demonstrated heightened in vitro proliferation, self-renewal, and invasive capacity. Orthotopic transplantation of CD133(+) cells led to the formation of heterogeneous tumors that were phenocopies of the original patient tumor. In this article, the authors discuss the complex regulation of CD133 expression in gliomas, its role in tumorigenesis, and its potential as a marker for targeted and personalized therapeutic intervention.

引用

页码：391 / +

页数：16

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