Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science

被引：24

作者：

Skeldon, KD ^{[1
]}

Gibson, GM ^{[1
]}

Wyse, CA ^{[1
]}

McMillan, LC ^{[1
]}

Monk, SD ^{[1
]}

Longbottom, C ^{[1
]}

Padgett, MJ ^{[1
]}

机构：

[1] Univ Glasgow, Dept Phys, Glasgow G12 8QQ, Lanark, Scotland

来源：

APPLIED OPTICS | 2005年 / 44卷 / 22期

关键词：

D O I：

10.1364/AO.44.004712

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity >= 70 ppt and response time from >= 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential. (c) 2005 Optical Society of America.

引用

页码：4712 / 4721

页数：10

共 27 条

[1] Breath alkanes as a marker of oxidative stress in different clinical conditions [J].

Aghdassi, E ;

Allard, JP .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (06) :880-886

[2] AN INVESTIGATION OF THE INCIDENCE OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD) IN RANDOM-POPULATIONS OF SWISS HORSES [J].

BRACHER, V ;

VONFELLENBERG, R ;

WINDER, CN ;

GRUENIG, G ;

HERMANN, M ;

KRAEHENMANN, A .

EQUINE VETERINARY JOURNAL, 1991, 23 (02) :136-141

[3] Real-time monitoring of ethane in human breath using mid-infrared cavity leak-out spectroscopy [J].

Dahnke, H ;

Kleine, D ;

Hering, P ;

Mürtz, M .

APPLIED PHYSICS B-LASERS AND OPTICS, 2001, 72 (08) :971-975

[4]

DAUGHERTY MS, 1988, DRUG METAB DISPOS, V16, P666

[5] A field-portable, laser-diode spectrometer for the ultra-sensitive detection of hydrocarbon gases [J].

Gibson, G ;

Monk, SD ;

Padgett, M .

JOURNAL OF MODERN OPTICS, 2002, 49 (5-6) :769-776

[6] OFF-AXIS PATHS IN SPHERICAL MIRROR INTERFEROMETERS [J].

HERRIOTT, D ;

KOMPFNER, R ;

KOGELNIK, H .

APPLIED OPTICS, 1964, 3 (04) :523-&

[7] Oil and gas prospecting by ultra-sensitive optical gas detection with inverse gas dispersion modelling [J].

Hirst, B ;

Gibson, G ;

Gillespie, S ;

Archibald, I ;

Podlaha, O ;

Skeldon, KD ;

Courtial, J ;

Monk, S ;

Padgett, M .

GEOPHYSICAL RESEARCH LETTERS, 2004, 31 (12) :L121151-4

[8]

KHARITONOV SA, 2003, DIS MARKERS EXHALED, pCH14

[9]

KIRSCHVINK N, 1999, EQUINE VET J S, V30, P88

[10]

KNEEPKENS CMF, 1994, FREE RADICAL BIO MED, V17, P127

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