RETRACTED: miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis (Retracted article. See vol. 707, 2019)

被引：23

作者：

Huang, Qiuhong ^{[1
,2
]}

Zheng, Yiqing ^{[1
,2
]}

Ou, Yongkang ^{[1
,2
]}

Xiong, Hao ^{[1
,2
]}

Yang, Haidi ^{[1
,2
]}

Zhang, Zhigang ^{[1
,2
]}

Chen, Suijun ^{[1
,2
]}

Ye, Yongyi ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Otolaryngol HNS, 107 Yanjiang West Rd, Guangzhou 510120, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Inst Hearing & Speech Language Sci, Guangzhou, Guangdong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2017年 / 661卷

基金：

中国国家自然科学基金;

关键词：

Apoptosis; Bcl-2; Cochlea; miR-34a; Presbycusis; OXIDATIVE STRESS; AUDITORY-CORTEX; MOUSE MODEL; EXPRESSION; COCHLEA; BCL-2; MICE; ACTIVATION; MECHANISMS; GENES;

D O I：

10.1016/j.neulet.2017.07.044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expression of Bcl-2 decreased. Increasing the amount of a miR-34a mimetic in a mouse auditory cell line (HEI-OC1) inhibited Bcl-2, leading to enhanced apoptosis; in contrast, miR-34a inhibition produced the opposite effect. Our results support a link between age-related cochlear hair cell apoptosis and miR-34a/Bc1-2 signaling. The latter may thus serve as a potential target for AHL therapy. (C) 2017 Elsevier B.V. All rights reserved.

引用

收藏

页码：51 / 56

页数：6

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