Effects of alcohol withdrawal on 24 hour ambulatory blood pressure among alcohol-dependent patients

被引:12
作者
Estruch, R
Sacanella, E
De la Sierra, A
Aguilera, MT
Antúnez, E
Nicolás, JM
Fernández-Solá, J
Coca, A
Urbano-Márquez, A
机构
[1] Univ Barcelona, Hosp Clin, IDIBAPS, Alcohol Unit, Barcelona, Spain
[2] Univ Barcelona, Hosp Clin, IDIBAPS, Hypertens Unit, Barcelona, Spain
[3] Univ Barcelona, Hosp Clin, IDIBAPS, Dept Internal Med, Barcelona, Spain
关键词
blood pressure; ethanol; alcohol dependence; hypertension; 24-hr ambulatory blood; pressure monitoring;
D O I
10.1097/01.ALC.0000100944.02340.46
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Although epidemiologic studies have reported an association between alcohol intake and high blood pressure (BP), the results of intervention studies have shown inconsistent results. We embarked on a study to determine whether different subgroups of alcohol-dependent patients may be identified in relation to the effect of alcohol on BP. Methods: Fifty alcohol-dependent men (mean age, 41.4 years) received 0.4 g of ethanol per kilogram of body weight every 4 hr in 200 ml of orange juice during 24 hr and the same amount of orange juice without ethanol during another 24 hr. Twenty-four hour ambulatory BP monitoring was performed during ethanol and orange juice intakes, as was hormonal and biochemical analysis. Results: Thirty-five (75%) alcohol-dependent men were normotensive and 15 (30%) hypertensive. Eighteen (51%) normotensive and 12 (80%) hypertensive subjects showed a significant decrease in 24 hr mean BP after ethanol withdrawal (mean decrease of 8.4 mm Hg [95% confidence interval, -11.2 to -5.7] and 12.5 mm Hg [confidence interval, -16.2 to -8.8], respectively) and were considered as sensitive to alcohol. The remaining alcohol-dependent subjects were considered as resistant to alcohol. Normotensive subjects sensitive to ethanol showed a significantly greater left ventricular mass and a significantly lower ejection fraction than those normotensive patients whose BP did not change after ethanol withdrawal (both P < 0.01). Conclusions: More than three fourths of the hypertensive and more than half of the normotensive alcohol-dependent patients showed sensitivity to the pressor effects of ethanol. Impairment also was observed in heart function in normotensive patients sensitive to the pressor effects of ethanol.
引用
收藏
页码:2002 / 2008
页数:7
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