Malaria: progress, perils, and prospects for eradication

被引：471

作者：

Greenwood, Brian M. ^{[3
]}

Fidock, David A. ^{[4
,5
]}

Kyle, Dennis E. ^{[6
]}

Kappe, Stefan H. I. ^{[1
,2
]}

Alonso, Pedro L. ^{[7
]}

Collins, Frank H. ^{[8
]}

Duffy, Patrick E. ^{[1
,2
]}

机构：

[1] Univ Washington, Seattle Biomed Res Inst, Malaria Program, Seattle, WA 98109 USA

[2] Univ Washington, Dept Pathobiol, Seattle, WA 98109 USA

[3] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England

[4] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

[5] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[6] Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL USA

[7] Univ Barcelona, Barcelona Ctr Int Hlth Res, Barcelona, Spain

[8] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 04期

关键词：

D O I：

10.1172/JCI33996

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.

引用

页码：1266 / 1276

页数：11

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