Differentiation inhibitory factor nm23 as a prognostic factor for acute myeloid leukemia

被引：30

作者：

Okabe-Kado, J ^{[1
]}

Kasukabe, T ^{[1
]}

Honma, Y ^{[1
]}

机构：

[1] Saitama Canc Ctr, Res Inst, Dept Chemotherapy, Ina, Saitama 3620806, Japan

来源：

LEUKEMIA & LYMPHOMA | 1998年 / 32卷 / 1-2期

关键词：

differentiation inhibitory factor; nm23; acute myeloid leukemia; prognostic factor;

D O I：

10.3109/10428199809059243

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The differentiation inhibitory factor nm23 inhibits the differentiation of murine and human myeloid leukemia cells. The inhibition of differentiation may be associated with the aggressive behavior of leukemia. To clarify the role of nm23 in human myeloid leukemia, we investigated the relative levels of nm23-H1, nm23-H2 and c-myc transcripts in bone marrow and blood samples from 110 patients with acute myeloid leukemia (AML) using the reverse transcriptase polymerase chain reaction. The expression levels of nm23-H1 and nm23-H2 in these AML samples were significantly higher than in normal blood cells, and a higher level of nm23-H1 expression was correlated with poor prognosis for AML patients. Analysis of the correlation between nm23 expression and clinical parameters demonstrated that increased nm23-H1 mRNA levels were associated with resistance to initial chemotherapy and reduced overall survival. Multivariate analysis of putative prognostic factors revealed that elevated nm23-H1 mRNA levels significantly influenced the prognosis of patients with AML, particularly in AML-MS.

引用

页码：19 / 28

页数：10

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