Antinephritis and radical scavenging activity of prenylflavonoids

被引：93

作者：

Fukai, T

Satoh, K

Nomura, T

Sakagami, H

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 5728510, Japan

[2] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 1428555, Japan

[3] Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan

来源：

FITOTERAPIA | 2003年 / 74卷 / 7-8期

关键词：

Morus alba; Artocarpus communis; Glycyrrhiza uralensis; Glycyrrhiza inflata; prenylflavonoids; antinephritis; superoxide anion radical;

D O I：

10.1016/j.fitote.2003.07.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from Morus alba, Artocarpus communis, Glycyrrhiza uralensis and G. inflata, was evaluated in mice with glomerular disease (Masugi-nephritis). Oral administrations of artonin E (2) or licochalcone A (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. ESR spectroscopy demonstrated that morusin (1) and licorisoflavan A (5) increased the radical intensity of sodium ascorbate by about two times. Morusin, licoricidin (3), licochalcone A and licorisoflavan A showed weak scavenging activity against superoxide anion radical. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：720 / 724

页数：5

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