Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma

被引:395
作者
Chan, ATC [1 ]
Leung, SF
Ngan, RKC
Teo, PML
Lau, WH
Kwan, WH
Hui, EP
Yiu, HY
Yeo, W
Cheung, FY
Yu, KH
Chiu, KW
Chan, DT
Mok, TSK
Yau, S
Yuen, KT
Mo, FKF
Lai, MMP
Ma, BBY
Kam, MKM
Leung, TWT
Johnson, PJ
Choi, PHK
Zee, BCY
机构
[1] Chinese Univ Hong Kong, Dept Clin Oncol, Prince Wales Hosp, Sir YK Pao Ctr Canc, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Sch Publ Hlth, Ctr Clin Trials, Sha Tin 100083, Peoples R China
关键词
D O I
10.1093/jnci/dji084
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This phase III randomized study compared concurrent cisplatin-radiotherapy (CRT) versus radiotherapy (RT) alone in patients with locoregionally advanced nasopharyngeal carcinoma. A total of 350 patients were randomly assigned to receive external RT alone or concurrently with cisplatin at a dosage of 40 mg/m(2) weekly. The primary endpoint was overall survival, and the median follow-up was 5.5 years. The 5-year overall survival was 58.6% (95% confidence interval [CI] = 50.9% to 66.2%) for the RT arm and 70.3% (95% CI = 63.4% to 77.3%) for the CRT arm. In Cox regression analysis adjusted for T stage, age, and overall stage, the difference in overall survival was statistically significantly in favor of concurrent CRT (P = .049, hazard ratio [HR] = 0.71 [95% CI = 0.5 to 1.01]). Subgroup analysis demonstrated that there was no difference between overall survival in the arms for T1/T2 stage (P = .74, HR = 0.93 [95% CI = 0.59 to 1.4]), whereas there was a difference between the arms for T3/T4 stage (P = .013, HR = 0.51[95% CI = 0.3 to 0.88]), favoring the CRT arm. The regimen of weekly concurrent CRT is a promising standard treatment strategy for locoregionally advanced nasopharyngeal carcinoma patients.
引用
收藏
页码:536 / 539
页数:4
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