Heterocyclic o-aminonitriles:: Preparation of pyrazolo [3,4-d]-pyrimidines with modification of the substituents at the 1-position

被引：37

作者：

Al-Afaleq, EI ^{[1
]}

Abubshait, SA ^{[1
]}

机构：

[1] Girls Coll 838, Fac Sci, Dept Chem, Dammam 31113, Saudi Arabia

来源：

MOLECULES | 2001年 / 6卷 / 07期

关键词：

o-aminonitriles; ketene acetals; pyrazolopyrimidines;

D O I：

10.3390/60700621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene SS-acetals (1a), S,N-acetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-(p-tolyl) pyridazin3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities.

引用

页码：621 / 638

页数：18

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