Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death

被引：111

作者：

Lee, Jin-Koo ^{[1
,4
]}

Won, Je-Seong ^{[1
,2
]}

Singh, Avtar K. ^{[2
,3
]}

Singh, Inderjit ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Dept Pathol, Charleston, SC 29425 USA

[3] Ralph H Johnson VA Med Ctr, Charleston, SC USA

[4] Hallym Univ, Inst Nat Med, Chunchon, South Korea

来源：

NEUROSCIENCE LETTERS | 2008年 / 440卷 / 03期

关键词：

atorvastatin; excitotoxicity; inflammation; hippocampus; kainic acid; lovastatin and seizure;

D O I：

10.1016/j.neulet.2008.05.112

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Statins are inhibitors of HMG-CoA reductase that have been recently recognized as anti-inflammatory and neuroprotective drugs. Herein, we investigated anti-excitotoxic and anti-seizure effects of statins by using kainic acid (KA)-rat seizure model, an animal model for temporal lobe epilepsy and excitotoxic neurodegeneration. We observed that pre-treatment with Lipitor (atorvastatin) efficiently reduced KA-induced seizure activities, hippocampal neuron death, monocyte infiltration and proinflammatory gene expression. In addition, we also observed that lovastatin treatment attenuated KA- or glutamate-induced excitotoxicity of cultured hippocampal neurons. These observations suggest a potential for use of statin treatment in modulation of seizures and other neurological diseases associated with excitotoxicity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：260 / 264

页数：5

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