Investigation and Serologic Follow-Up of Contacts of Early Confirmed Case-Patient with COVID-19, Washington, USA

被引：6

作者：

Chu, Victoria T. ^{[1
]}

Freeman-Ponder, Brandi ^{[1
]}

Lindquist, Scott ^{[2
]}

Spitters, Christopher ^{[3
]}

Kawakami, Vance ^{[4
]}

Dyal, Jonathan W. ^{[1
]}

Clark, Shauna ^{[4
]}

Bruce, Hollianne ^{[1
,3
]}

Duchin, Jeffrey S. ^{[4
,5
]}

DeBolt, Chas ^{[2
]}

Podczervinski, Sara ^{[2
]}

D'Angeli, Marisa ^{[2
]}

Pettrone, Kristen ^{[1
]}

Zacks, Rachael ^{[1
]}

Vahey, Grace ^{[1
]}

Holshue, Michelle L. ^{[1
,2
]}

Lang, Misty ^{[2
]}

Burke, Rachel M. ^{[1
]}

Rolfes, Melissa A. ^{[1
]}

Marlow, Mariel ^{[1
]}

Midgley, Claire M. ^{[1
]}

Lu, Xiaoyan ^{[1
]}

Lindstrom, Stephen ^{[1
]}

Hall, Aron J. ^{[1
]}

Fry, Alicia M. ^{[1
]}

Thornburg, Natalie J. ^{[1
]}

Gerber, Susan, I ^{[1
]}

Pillai, Satish K. ^{[1
]}

Biggs, Holly M. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, 1600 Clifton Dr NE,Mailstop H24-5, Atlanta, GA 30329 USA

[2] Washington State Dept Publ Hlth, Shoreline, WA, Australia

[3] Snohomish Hlth Dist, Everett, WA USA

[4] Publ Hlth Seattle & King Cty, Seattle, WA USA

[5] Univ Washington, Seattle, WA 98195 USA

来源：

EMERGING INFECTIOUS DISEASES | 2020年 / 26卷 / 08期

关键词：

SPIKE;

D O I：

10.3201/eid2608.201423

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the United States. Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. Fifty contacts were identified and 38 (76%) were interviewed, of whom 11 (29%) reported unprotected face-to-face interaction with the case-patient. Thirty-seven (74%) had respiratory specimens tested by rRT-PCR, and all tested negative. Twenty-three (46%) had ELISA performed on serum samples collected approximate to 6 weeks after exposure, and none had detectable antibodies to SARS-CoV-2. Among contacts who were tested, no secondary transmission was identified in this investigation, despite unprotected close interactions with the infectious case-patient.

引用

页码：1671 / 1678

页数：8

共 17 条

[1]

Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19-United States, January-February 2020 [J].

Burke, Rachel M. ;

Midgley, Claire M. ;

Dratch, Alissa ;

Fenstersheib, Marty ;

Haupt, Thomas E. ;

Holshue, Michelle ;

Ghinai, Isaac ;

Jarashow, M. Claire ;

Lo, Jennifer ;

McPherson, Tristan D. ;

Rudman, Sara ;

Scott, Sarah ;

Hall, Aron J. ;

Fry, Alicia M. ;

Rolfes, Melissa A. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (09) :245-246

[2]

Centers for Disease Control and Prevention, 2020, Coronavirus Disease 2019 (COVID-19): Cases in the U.S.

[3]

Centers for Disease Control and Prevention, 2020, UPD INT GUID OUTBR 2

[4]

Centers for Disease Control and Prevention, 2020, CDC 2019 NOV COR 201

[5]

Two Years after Pandemic Influenza A/2009/H1N1: What Have We Learned? [J].

Cheng, Vincent C. C. ;

To, Kelvin K. W. ;

Tse, Herman ;

Hung, Ivan F. N. ;

Yuen, Kwok-Yung .

CLINICAL MICROBIOLOGY REVIEWS, 2012, 25 (02) :223-263

[6]

First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA [J].

Ghinai, Isaac ;

McPherson, Tristan D. ;

Hunter, Jennifer C. ;

Kirking, Hannah L. ;

Christiansen, Demian ;

Joshi, Kiran ;

Rubin, Rachel ;

Morales-Estrada, Shirley ;

Black, Stephanie R. ;

Pacilli, Massimo ;

Fricchione, Marielle J. ;

Chugh, Rashmi K. ;

Walblay, Kelly A. ;

Ahmed, N. Seema ;

Stoecker, William C. ;

Hasan, Nausheen F. ;

Burdsall, Deborah P. ;

Reese, Heather E. ;

Wallace, Megan ;

Wang, Chen ;

Moeller, Darcie ;

Korpics, Jacqueline ;

Novosad, Shannon A. ;

Benowitz, Isaac ;

Jacobs, Max W. ;

Dasari, Vishal S. ;

Patel, Megan T. ;

Kauerauf, Judy ;

Charles, E. Matt ;

Ezike, Ngozi O. ;

Chu, Victoria ;

Midgley, Claire M. ;

Rolfes, Melissa A. ;

Gerber, Susan I. ;

Lu, Xiaoyan ;

Lindstrom, Stephen ;

Verani, Jennifer R. ;

Layden, Jennifer E. .

LANCET, 2020, 395 (10230) :1137-1144

[7]

First Case of 2019 Novel Coronavirus in the United States [J].

Holshue, Michelle L. ;

DeBolt, Chas ;

Lindquist, Scott ;

Lofy, Kathy H. ;

Wiesman, John ;

Bruce, Hollianne ;

Spitters, Christopher ;

Ericson, Keith ;

Wilkerson, Sara ;

Tural, Ahmet ;

Diaz, George ;

Cohn, Amanda ;

Fox, LeAnne ;

Patel, Anita ;

Gerber, Susan I. ;

Kim, Lindsay ;

Tong, Suxiang ;

Lu, Xiaoyan ;

Lindstrom, Steve ;

Pallansch, Mark A. ;

Weldon, William C. ;

Biggs, Holly M. ;

Uyeki, Timothy M. ;

Pillai, Satish K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (10) :929-936

[8]

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[9]

Kujawski SA, 2020, NAT MED, DOI [10.1038/s41591-020-0877-5, DOI 10.1038/S41591-020-0877-5]

[10]

COVID-19 and the Risk to Health Care Workers: A Case Report [J].

Ng, Kangqi ;

Poon, Beng Hoong ;

Puar, Troy Hai Kiat ;

Quah, Jessica Li Shan ;

Loh, Wann Jia ;

Wong, Yu Jun ;

Tan, Thean Yen ;

Raghuram, Jagadesan .

ANNALS OF INTERNAL MEDICINE, 2020, 172 (11) :766-+

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