Role of reactive oxygen species (ROS) in apoptosis induction

被引：2553

作者：

Simon, HU

Haj-Yehia, A

Levi-Schaffer, F

机构：

[1] Univ Bern, Dept Pharmacol, CH-3010 Bern, Switzerland

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Sch Pharm, Dept Pharmaceut, IL-91010 Jerusalem, Israel

来源：

APOPTOSIS | 2000年 / 5卷 / 05期

关键词：

apoptosis; death receptors; inflammation; reactive oxygen species (ROS);

D O I：

10.1023/A:1009616228304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

引用

页码：415 / 418

页数：4

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