Pathogenicity of IgG in patients with IgG4-related disease

被引：176

作者：

Shiokawa, Masahiro ^{[1
]}

Kodama, Yuzo ^{[1
]}

Kuriyama, Katsutoshi ^{[1
]}

Yoshimura, Kenichi ^{[2
]}

Tomono, Teruko ^{[1
]}

Morita, Toshihiro ^{[1
]}

Kakiuchi, Nobuyuki ^{[1
]}

Matsumori, Tomoaki ^{[1
]}

Mima, Atsushi ^{[1
]}

Nishikawa, Yoshihiro ^{[1
]}

Ueda, Tatsuki ^{[1
]}

Tsuda, Motoyuki ^{[1
]}

Yamauchi, Yuki ^{[1
]}

Minami, Ryuki ^{[1
]}

Sakuma, Yojiro ^{[1
]}

Ota, Yuji ^{[1
]}

Maruno, Takahisa ^{[1
]}

Kurita, Akira ^{[1
]}

Sawai, Yugo ^{[1
]}

Tsuji, Yoshihisa ^{[1
]}

Uza, Norimitsu ^{[1
]}

Matsumura, Kazuyoshi ^{[3
]}

Watanabe, Tomohiro ^{[1
]}

Notohara, Kenji ^{[4
]}

Tsuruyama, Tatsuaki ^{[5
]}

Seno, Hiroshi ^{[1
]}

Chiba, Tsutomu ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[2] Kyoto Univ Hosp, Translat Res Ctr, Kyoto, Japan

[3] Shiga Med Ctr Adults, Dept Gastroenterol & Hepatol, Moriyama, Shiga, Japan

[4] Kurashiki Cent Hosp, Dept Anat Pathol, Kurashiki, Okayama, Japan

[5] Kyoto Univ Hosp, Dept Diagnost Pathol, Kyoto, Japan

来源：

GUT | 2016年 / 65卷 / 08期

关键词：

AUTOIMMUNE PANCREATITIS; DIAGNOSTIC-CRITERIA; CARBONIC-ANHYDRASE; SCLEROSING PANCREATITIS; BLISTER INDUCTION; AUTOANTIBODIES; CHOLANGITIS; ANTIBODIES; SERUM; IDENTIFICATION;

D O I：

10.1136/gutjnl-2015-310336

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Objective IgG4-related disease (IgG4-RD) is a systemic disease characterised by elevated serum IgG4 and IgG4-positive lymphoplasmacytic infiltration in the affected tissues. The pathogenic role of IgGs, including IgG4, in patients with IgG4-RD, however, is unknown. Design We examined the pathogenic activity of circulating IgGs in patients with IgG4-RD by injecting their IgGs into neonatal male Balb/c mice. Binding of patient IgGs to pancreatic tissue was also analysed in an ex vivo mouse organ culture model and in tissue samples from patients with autoimmune pancreatitis (AIP). Results Subcutaneous injection of patient IgG, but not control IgG, resulted in pancreatic and salivary gland injuries. Pancreatic injury was also induced by injecting patient IgG1 or IgG4, with more destructive changes induced by IgG1 than by IgG4. The potent pathogenic activity of patient IgG1 was significantly inhibited by simultaneous injection of patient IgG4. Binding of patient IgG, especially IgG1 and IgG4, to pancreatic tissue was confirmed in both the mouse model and AIP tissue samples. Conclusions IgG1 and IgG4 from patients with IgG4-RD have pathogenic activities through binding affected tissues in neonatal mice.

引用

页码：1322 / 1332

页数：11

共 34 条

[1]

INDUCTION OF PEMPHIGUS IN NEONATAL MICE BY PASSIVE TRANSFER OF IGG FROM PATIENTS WITH THE DISEASE [J].