Role of toll-like receptors in HMGB1 release from macrophages

被引：19

作者：

Pisetsky, David S.

Jiang, Weiwen

机构：

[1] VA Med Ctr, Durham, NC 27705 USA

[2] Duke Univ, Med Ctr, Dept Med, Div Rheumatol & Immunol, Durham, NC 27710 USA

来源：

AUTOIMMUNITY, PART A: BASIC PRINCIPLES AND NEW DIAGNOSTIC TOOLS | 2007年 / 1109卷

关键词：

macrophage; toll-like receptor; HMGB1; LPS; apoptosis;

D O I：

10.1196/annals.1398.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.

引用

收藏

页码：58 / 65

页数：8

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