Spatial dynamics and molecular ecology of North American rabies

被引:28
作者
Real, LA
Russell, C
Waller, L
Smith, D
Childs, J
机构
[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
[2] Emory Univ, Ctr Dis Ecol, Atlanta, GA 30322 USA
[3] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
[4] Emory Univ, Dept Biostat, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[5] Fogarty Int Ctr, Bethesda, MD 20892 USA
关键词
D O I
10.1093/jhered/esi031
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Rabies, caused by a single-stranded RNA virus, is arguably the most important viral zoonotic disease worldwide. Although endemic throughout many regions for millennia, rabies is also undergoing epidemic expansion, often quite rapid, among wildlife populations across regions of Europe and North America. A current rabies epizootic in North America is largely attributable to the accidental introduction of a particularly well-adapted virus variant into a naive raccoon population along the Virginia/West Virginia border in the mid-1970s. We have used the extant database on the spatial and temporal occurrence of rabid raccoons across the eastern United States to construct predictive models of disease spread and have tied patterns of emergence to local environmental variables, genetic heterogeneity, and host specificity. Rabies will continue to be a remarkable model system for exploring basic issues in the temporal and spatial dynamics of expanding infectious diseases and examining ties between disease population ecology and evolutionary genetics at both micro- and macro-evolutionary time scales.
引用
收藏
页码:253 / 260
页数:8
相关论文
共 34 条
[1]  
[Anonymous], MAMMALS ADIRONDACK R
[2]  
BOGEL K, 1976, B WORLD HEALTH ORGAN, V54, P433
[3]  
BURRIDGE MJ, 1986, RABIES FLORIDA
[4]  
*CDC, 1997, MMWR-MORBID MORTAL W, V45, P1117
[5]  
Childs J. E., 2002, MOL EPIDEMIOLOGY HUM, P273
[6]   Rabies Epizootics Among Raccoons Vary Along a North-South Gradient in the Eastern United States [J].
Childs, James E. ;
Curns, Aaron T. ;
Dey, Meghan E. ;
Real, Les A. ;
Rupprecht, Charles E. ;
Krebs, John W. .
VECTOR-BORNE AND ZOONOTIC DISEASES, 2001, 1 (04) :253-+
[7]   Predicting the local dynamics of epizootic rabies among raccoons in the United States [J].
Childs, JE ;
Curns, AT ;
Dey, ME ;
Real, LA ;
Feinstein, L ;
Bjornstad, ON ;
Krebs, JW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13666-13671
[8]  
COYNE MJ, 1989, AM J VET RES, V50, P2148
[9]   Molecular epidemiology of enzootic rabies in California [J].
Crawford-Miksza, LK ;
Wadford, DA ;
Schnurr, DP .
JOURNAL OF CLINICAL VIROLOGY, 1999, 14 (03) :207-219
[10]   Cluster of rabies cases of probable bat origin among red foxes in Prince Edward Island, Canada [J].
Daoust, PY ;
Wandeler, AI ;
Casey, GA .
JOURNAL OF WILDLIFE DISEASES, 1996, 32 (02) :403-406